|
|
Analysis of experimental ECG
Mackových, Marek ; Kolářová, Jana (referee) ; Ronzhina, Marina (advisor)
This thesis is focused on the analysis of experimental ECG records drawn up in isolated rabbit hearts and aims to describe changes in EKG caused by ischemia and left ventricular hypertrophy. It consists of a theoretical analysis of the problems in the evaluation of ECG during ischemia and hypertrophy, and describes an experimental ECG recording. Theoretical part is followed by a practical section which describes the method for calculating morphological parameters, followed by ROC analysis to evaluate their suitability for the classification of hypertrophy and at the end is focused on classification.
|
|
|
Role of echocardiography in the evaluation of functional and structural changes of the myocardium
Rob, Daniel ; Linhart, Aleš (advisor) ; Pudil, Radek (referee) ; Málek, Filip (referee)
Echocardiography plays a key role in the evaluation of functional and structural changes of the heart. Fabry disease (FD) is a genetic (X-linked) lysosomal storage disease caused by mutations in the gene for alpha-galactosidase A. Cardiovascular involvement is a major cause of morbidity and mortality in FD. The aim of our work was to refine the diagnosis and risk stratification of Fabry cardiac involvement using echocardiography. In the first part of our retrospective project, we analysed the relationship between the uric acid level, development, and progression of left ventricular (LV) hypertrophy and adverse events. Our results showed a strong relationship between uric acid level and progression of LV hypertrophy, mortality, and cardiovascular events. Uric acid can be used as a marker of cardiovascular risk in FD. In the second part of our retrospective project, we analysed the diagnostic value of tissue doppler imaging (TDI) of mitral annular velocities in Fabry cardiomyopathy. Despite the lower TDI mitral annular velocities in FD, the overlap with the general population is too large to allow reliable diagnosis of FD in routine clinical practice. In the prospective study, we analysed the prevalence, characteristics, prognosis and validity of the current echocardiographic criteria for heart...
|
|
|
Aldosterone synthase in arterial hypertension and possible influence of its genenetic polymorphism on left ventricular hypertrophy
Heller, Samuel ; Horký, Karel (advisor) ; Málková, Jana (referee) ; Widimský, Jiří (referee)
Part I. The aldosterone synthase gene (CYP11B2) polymorphism T-344C in blood pressure and left ventricular hypertrophy. BACKGROUND: Aldosterone is a key cardovascular hormone, it significantly influences volume, pressure and electrolyte balance. Aldosterone plays an important role in development of left ventricular (LV) hypertrophy and myocardial fibrosis. The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. DESIGN AND METHODS: We assessed the influence of the T-344C polymorphism of aldosterone synthase - the rate-limiting enzyme in aldosterone biosynthesis - on the structure of the left ventricle in young normotensive men. The population included 113 normotensive mid-European Caucasian men aged 18-40 years (mean 27 +/- 5 years). We also studied the association of -344T/C polymorphism of the CYP11B2 gene with the presence and severity of hypertension in 369 individuals, of whom 213 were hypertensive patients (139 controlled hypertensive, 74 resistant hypertensive) and 156 were healthy normotensive subjects. The genotype was assessed using polymerase chain reaction with subsequent cleavage with restriction enzyme HAEIII (restriction fragment length polymorphism method) and visualization with ethidium bromide. Plasma renin activity (PRA) and plasma...
|
|
|
Analysis of experimental ECG
Mackových, Marek ; Kolářová, Jana (referee) ; Ronzhina, Marina (advisor)
This thesis is focused on the analysis of experimental ECG records drawn up in isolated rabbit hearts and aims to describe changes in EKG caused by ischemia and left ventricular hypertrophy. It consists of a theoretical analysis of the problems in the evaluation of ECG during ischemia and hypertrophy, and describes an experimental ECG recording. Theoretical part is followed by a practical section which describes the method for calculating morphological parameters, followed by ROC analysis to evaluate their suitability for the classification of hypertrophy and at the end is focused on classification.
|
guest ::
